Gene information
Official symbol APOA1
Official full name apolipoprotein A1
Gene type protein-coding gene
Chromosome11q23.3
Gene familyApolipoproteins
Resources
Entrez Gene 335
HGNC HGNC:600
Ensembl ENSG00000118137
Vega OTTHUMG00000046112
UCSC uc001ppv.2
GO terms: 149 records
GO Description Category LogP Number of genes Detail
GO:0001540 amyloid-beta binding GO Molecular Functions -10.7345181 13 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001959 regulation of cytokine-mediated signaling pathway GO Biological Processes -13.0991884 33 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002698 negative regulation of immune effector process GO Biological Processes -11.7829906 16 More
GO:0002700 regulation of production of molecular mediator of immune response GO Biological Processes -19.7615296 26 More
GO:0002701 negative regulation of production of molecular mediator of immune response GO Biological Processes -8.92314992 9 More
GO:0002719 negative regulation of cytokine production involved in immune response GO Biological Processes -9.55471636 12 More
GO:0005319 lipid transporter activity GO Molecular Functions -5.47143795 11 More
GO:0005496 steroid binding GO Molecular Functions -8.57765300 12 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0005769 early endosome GO Cellular Components -6.25251045 19 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006066 alcohol metabolic process GO Biological Processes -16.7128396 29 More
GO:0006869 lipid transport GO Biological Processes -16.6388990 29 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0008202 steroid metabolic process GO Biological Processes -19.3229835 29 More
GO:0008203 cholesterol metabolic process GO Biological Processes -19.4799126 22 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0008610 lipid biosynthetic process GO Biological Processes -6.38047816 23 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010565 regulation of cellular ketone metabolic process GO Biological Processes -15.3155739 32 More
GO:0010631 epithelial cell migration GO Biological Processes -10.0481870 21 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010810 regulation of cell-substrate adhesion GO Biological Processes -12.3653476 37 More
GO:0010872 regulation of cholesterol esterification GO Biological Processes -10.0035192 7 More
GO:0010873 positive regulation of cholesterol esterification GO Biological Processes -7.55914528 5 More
GO:0010874 regulation of cholesterol efflux GO Biological Processes -13.5117096 13 More
GO:0010875 positive regulation of cholesterol efflux GO Biological Processes -12.4669764 10 More
GO:0010876 lipid localization GO Biological Processes -20.1994935 34 More
GO:0015248 sterol transporter activity GO Molecular Functions -5.41560423 6 More
GO:0015485 cholesterol binding GO Molecular Functions -6.09984616 12 More
GO:0015748 organophosphate ester transport GO Biological Processes -5.98331847 11 More
GO:0015850 organic hydroxy compound transport GO Biological Processes -17.9399475 23 More
GO:0015914 phospholipid transport GO Biological Processes -7.60367088 11 More
GO:0015918 sterol transport GO Biological Processes -16.3959877 17 More
GO:0016125 sterol metabolic process GO Biological Processes -19.5624674 23 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019217 regulation of fatty acid metabolic process GO Biological Processes -12.5607102 15 More
GO:0019218 regulation of steroid metabolic process GO Biological Processes -14.2494824 17 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0030139 endocytic vesicle GO Cellular Components -10.5530816 23 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030301 cholesterol transport GO Biological Processes -18.3843949 17 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031210 phosphatidylcholine binding GO Molecular Functions -5.56986570 6 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032370 positive regulation of lipid transport GO Biological Processes -15.5410017 17 More
GO:0032371 regulation of sterol transport GO Biological Processes -19.2332049 29 More
GO:0032373 positive regulation of sterol transport GO Biological Processes -13.7255371 12 More
GO:0032374 regulation of cholesterol transport GO Biological Processes -19.2332049 29 More
GO:0032376 positive regulation of cholesterol transport GO Biological Processes -13.7255371 12 More
GO:0032489 regulation of Cdc42 protein signal transduction GO Biological Processes -5.88286021 4 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032691 negative regulation of interleukin-1 beta production GO Biological Processes -9.98402343 15 More
GO:0032692 negative regulation of interleukin-1 production GO Biological Processes -11.9554195 18 More
GO:0032934 sterol binding GO Molecular Functions -5.20663428 12 More
GO:0032956 regulation of actin cytoskeleton organization GO Biological Processes -4.25470878 32 More
GO:0032970 regulation of actin filament-based process GO Biological Processes -7.72273150 43 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0033344 cholesterol efflux GO Biological Processes -10.9607436 9 More
GO:0033700 phospholipid efflux GO Biological Processes -8.63513275 6 More
GO:0034114 regulation of heterotypic cell-cell adhesion GO Biological Processes -12.8696023 10 More
GO:0034364 high-density lipoprotein particle GO Cellular Components -15.5094832 12 More
GO:0034367 protein-containing complex remodeling GO Biological Processes -22.5554593 16 More
GO:0034368 protein-lipid complex remodeling GO Biological Processes -23.1924108 16 More
GO:0034369 plasma lipoprotein particle remodeling GO Biological Processes -23.1924108 16 More
GO:0034377 plasma lipoprotein particle assembly GO Biological Processes -8.18952769 7 More
GO:0034380 high-density lipoprotein particle assembly GO Biological Processes -6.77353044 5 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035023 regulation of Rho protein signal transduction GO Biological Processes -3.55619697 12 More
GO:0042157 lipoprotein metabolic process GO Biological Processes -6.61578697 11 More
GO:0042158 lipoprotein biosynthetic process GO Biological Processes -1.65025617 4 More
GO:0042277 peptide binding GO Molecular Functions -10.2245210 22 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042632 cholesterol homeostasis GO Biological Processes -21.5492593 34 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043178 alcohol binding GO Molecular Functions -5.93737043 9 More
GO:0043534 blood vessel endothelial cell migration GO Biological Processes -6.48443546 10 More
GO:0043542 endothelial cell migration GO Biological Processes -10.6625063 19 More
GO:0043691 reverse cholesterol transport GO Biological Processes -17.1886584 11 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045834 positive regulation of lipid metabolic process GO Biological Processes -24.1838255 28 More
GO:0045940 positive regulation of steroid metabolic process GO Biological Processes -11.4541194 10 More
GO:0046578 regulation of Ras protein signal transduction GO Biological Processes -3.44587232 19 More
GO:0046889 positive regulation of lipid biosynthetic process GO Biological Processes -14.1380112 16 More
GO:0046890 regulation of lipid biosynthetic process GO Biological Processes -16.6841590 23 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050764 regulation of phagocytosis GO Biological Processes -16.0793009 29 More
GO:0050766 positive regulation of phagocytosis GO Biological Processes -13.5971167 15 More
GO:0050994 regulation of lipid catabolic process GO Biological Processes -9.86212956 11 More
GO:0050997 quaternary ammonium group binding GO Molecular Functions -4.83197184 6 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051235 maintenance of location GO Biological Processes -6.64896142 13 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0051493 regulation of cytoskeleton organization GO Biological Processes -3.52271067 40 More
GO:0055088 lipid homeostasis GO Biological Processes -20.8046481 43 More
GO:0055091 phospholipid homeostasis GO Biological Processes -6.04894404 5 More
GO:0055092 sterol homeostasis GO Biological Processes -21.3864243 34 More
GO:0060191 regulation of lipase activity GO Biological Processes -10.2745708 13 More
GO:0060193 positive regulation of lipase activity GO Biological Processes -9.32996784 11 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0060759 regulation of response to cytokine stimulus GO Biological Processes -13.7003447 35 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062013 positive regulation of small molecule metabolic process GO Biological Processes -17.9792910 37 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0065005 protein-lipid complex assembly GO Biological Processes -7.77416886 7 More
GO:0071825 protein-lipid complex subunit organization GO Biological Processes -20.9970896 17 More
GO:0071827 plasma lipoprotein particle organization GO Biological Processes -21.6197515 17 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:0090130 tissue migration GO Biological Processes -11.7623300 24 More
GO:0090132 epithelium migration GO Biological Processes -9.75855830 21 More
GO:0090407 organophosphate biosynthetic process GO Biological Processes -3.52771570 18 More
GO:0097006 regulation of plasma lipoprotein particle levels GO Biological Processes -27.6960426 22 More
GO:0110053 regulation of actin filament organization GO Biological Processes -3.93783734 26 More
GO:0120009 intermembrane lipid transfer GO Biological Processes -4.61583694 6 More
GO:0120013 lipid transfer activity GO Molecular Functions -4.61583694 6 More
GO:0120015 sterol transfer activity GO Molecular Functions -6.64459385 6 More
GO:0120020 cholesterol transfer activity GO Molecular Functions -6.77152389 6 More
GO:1901615 organic hydroxy compound metabolic process GO Biological Processes -22.7091625 41 More
GO:1902652 secondary alcohol metabolic process GO Biological Processes -19.9585075 23 More
GO:1902903 regulation of supramolecular fiber organization GO Biological Processes -5.63791156 37 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905954 positive regulation of lipid localization GO Biological Processes -22.7388039 24 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04975 Fat digestion and absorption KEGG Pathway -5.93899775 11 More
hsa04979 Cholesterol metabolism KEGG Pathway -20.0696655 17 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
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Related drugs: 8 records
Related studies: 23 records
Molecular factor Omics type Application Objective MI type Reference
NM_000039.3:c.43+41T>C genomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Shioji K et al. J Hum Genet. 2004
NM_000039.3:c.-21+67C>T genomics myocardial infarction[diagnosis] myocardial infarction Dawar R et al. Am J Clin Pathol. 2010
NM_000039.3:c.-21+68G>A genomics myocardial infarction[diagnosis] myocardial infarction Dawar R et al. Am J Clin Pathol. 2010
NM_000039.3:c.-21+68G>A genomics recurrent cardiac events[prognosis (bad)] acute myocardial infarction Block R et al. Heart Int. 2009
apolipoprotein A-I proteomics myocardial infarction[diagnosis] myocardial infarction Buring JE et al. Circulation. 1992
apolipoprotein A-I proteomics myocardial infarction[diagnosis] myocardial infarction Schwartzkopff W et al. Atherosclerosis. 1990
apolipoprotein A-I proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Franzen J et al. Atherosclerosis. 1986
apolipoprotein A-I proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Maury CP et al. J Clin Pathol. 1988
apolipoprotein A-I proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Fager G et al. Atherosclerosis. 1980
apolipoprotein A-I proteomics myocardial infarction[diagnosis] myocardial infarction Marques-Vidal P et al. Atherosclerosis. 1995
apolipoprotein A-I proteomics acute myocardial infarction[diagnosis] acute myocardial infarction MBewu AD et al. Atherosclerosis. 1993
apolipoprotein A-I proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Woo J et al. Int J Cardiol. 1993
apolipoprotein A-I proteomics myocardial infarction[diagnosis] myocardial infarction Pay S et al. Int J Cardiol. 1997
apolipoprotein A-I proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Dahlen GH et al. J Intern Med. 1999
apolipoprotein A-I proteomics myocardial infarction[diagnosis] myocardial infarction Ladenvall P et al. Thromb Haemost. 2002
apolipoprotein A-I proteomics myocardial infarction[diagnosis] myocardial infarction Al-Muhtaseb N et al. Ann Saudi Med. 1992
apolipoprotein A-I proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Sharma R et al. Indian J Clin Biochem. 2001
apolipoprotein A-I proteomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Li BQ et al. Ups J Med Sci. 2018
apolipoprotein A-I proteomics stress hyperglycemia[prognosis (bad)] ST elevation myocardial infarction Li BQ et al. Ups J Med Sci. 2018
apolipoprotein A-I proteomics poor predictor coronary vessel lesion[other] non-ST elevation myocardial infarction Chen BD et al. Lipids Health Dis. 2019
apolipoprotein A-I proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Soria-Florido MT et al. Circulation. 2020
apolipoprotein A-I proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Thakkar H et al. Lipids Health Dis. 2020
apolipoprotein A-I proteomics myocardial infarction[diagnosis] myocardial infarction Thogersen AM et al. Eur J Cardiovasc Prev Rehabil. 2004
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